Angiogenesis

1. the formation of blood vessels during development
4. injection of matrigel into living tissue with test compounds and later removal in order to analyze vascularization
7. the formation of blood vessels from other blood vessels
8. the introduction of specific growth factors into a mouse cornea in order to observe vascularization
14. a secreted glycoprotein that acts as primary growth factor responsible for angiogenesis with several alternatively spliced forms
15. low oxygen conditions that promote angiogenesis

2. provides vascular tone
3. an in vitro 3D assay where cells are cultured on beads and then placed in gel in order observe vascularization
5. the inner layer of a blood vessel that contains endothelial cells and elastic fibers
6. a protein subunit that is normally hydroxylated and degraded but under hypoxic conditions will become active and promote VEGF production
8. an experiment to analyze vascularization where endothelial cells that are plated on matrigel organize into a network structure
9. act as a barrier between blood and tissue, prevent clotting normally though can support it when activated, and aids the immune response
10. the middle layer of a blood vessel that contains smooth muscle cells
11. the small blood vessels where gas exchange takes place
12. cells that serve as a thin layer around the endothelial cells in blood vessels to provide support
13. the outer layer of a blood vessel that contains collagen, elastin, and nerves