Anticonvulsants

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Across
  1. 2. Anti-convulsants can target GABA-gated ________ channels.
  2. 5. Barbituates have a ____ half life.
  3. 7. What drug can be used as mono-therapy or in adjunction with phenobarbitone?
  4. 9. What changes happen to the GABA receptor when benzodiazepines bind to the benzodiazepine receptor?
  5. 10. What add-on drug is often used for neuropathic pain?
  6. 12. Benzodiazepines work off the same made of action as the ______ form.
  7. 14. antidote for the overdose of benzodiazepines
  8. 15. What chloride channel opens when GABA receptors are activated.
  9. 17. Barbituates can result in ______.
  10. 18. Side effects of benzodiazepines are teratogenicity and ______.
  11. 21. Meaning it relies on GABA's effects on the chloride channel.
  12. 22. The ceiling effect of benzodiazepines means that maximal GABA binding will not pass _______.
  13. 25. Which barbituate causes a greater level of sedation?
  14. 27. What activation system does barbituates preferentially target?
  15. 28. serum drug _____ is essential for phenobarbitone.
  16. 30. What side effect does diazepam have and midazolam does not?
  17. 31. What does an influx of chloride cause within the neural cell?
Down
  1. 1. The loading dose of bromide is 600 mg/kg over 3-5 days, then maintenance dose of 30-40 mg/kg ______ per day.
  2. 3. Barbituates bind directly to the chloride channel, opening it wide, raising the __________ potential.
  3. 4. Why does the half-life of benzodiazepines not equal the duration of action?
  4. 6. What drug is thought to supress seizures without affecting neuronal excitability?
  5. 8. The mechanism of potassium bromide is ______.
  6. 11. phenobarbitone can induce ____ leading to sub-therapeutic levels and hepatotoxicity.
  7. 13. What drug uses a propylene glycol transport vehicle?
  8. 16. What drug is a partial agonist at the GABA receptor?
  9. 19. What is the take-home drug of choice?
  10. 20. Target receptors can include the _______ of sodium ion channels.
  11. 23. Benzodiazepines cause a _______ mediated skeletal muscle relaxation.
  12. 24. what drug may be used as an IV CRI to prevent ongoing seizures?
  13. 26. A target receptor of anti-convulsants is the inhibition of ______ neurotransmission.
  14. 29. The _______ at chloride ion channels are a target receptor.