APF OF THE URINARY SYSTEM

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Across
  1. 1. Functional role of APF in suppressing urothelial cell proliferation
  2. 3. Pelvic organ that stores urine and experiences APF-mediated changes
  3. 4. Cell division cycle phase often blocked or altered by APF activity
  4. 5. Epidermal growth factor measured alongside APF in urinary diagnostics
  5. 7. A substance like HB-EGF that counteracts the effects of APF
  6. 8. Urinary biomarker abbreviation standing for antiproliferative factor
  7. 10. Nucleoside whose cellular incorporation is suppressed by APF exposure
  8. 13. Kinase signaling pathway involved in APF-mediated growth suppression
  9. 14. Tumor suppressor protein mediating APF-induced growth inhibition
  10. 15. The specific biochemical classification of the APF molecule
  11. 16. Laboratory assay method used to measure biomarkers like HB-EGF and EGF
  12. 18. Common symptom experienced by patients with elevated urinary APF
  13. 19. The cellular pathway activated following APF binding
  14. 21. Sudden compelling need to urinate characteristic of APF-related bladder disorders
  15. 23. Liquid excretion fluid where APF is detected in most affected patients
  16. 24. The biological origin and development of disease influenced by APF
  17. 25. Abnormally high rate of urination associated with interstitial cystitis
  18. 26. Receptor family whose transmembrane segment shares homology with APF
  19. 27. Measurable biological indicator found in clinical tests, such as APF
Down
  1. 2. Chronic bladder condition marked by high urinary APF levels
  2. 5. Descriptive term for the mucosal cells lining the urinary bladder
  3. 6. Chromosomal state involving multiple sets induced by APF cell cycle arrest
  4. 8. Organic compounds forming the peptide backbone of APF
  5. 9. Bladder-stretching procedure that increases intraluminal APF antagonists
  6. 11. Eponymous name for the type of bladder ulcers studied alongside APF biomarkers
  7. 12. Cytoskeleton-associated protein 4 acting as a cellular receptor for APF
  8. 17. Growth factor that acts as a functional antagonist to APF
  9. 19. Terminal sugar moiety attached to the APF structure
  10. 20. Specialized lining of the urinary tract targeted by APF
  11. 22. Cell-surface molecule that binds APF to initiate signal transduction