BHS 316 Exam 2 Review

1. The ______ system is the network of vessels that returns interstitial fluid to bloodstream.
4. Molecule of microbes recognized by innate immune receptors.
5. 2, MHC class found primarily on professional antigen-presenting cells.
10. Organ that filters blood-borne pathogens.
12. A ____ cell is an APC that is especially important for priming naïve T cells.
13. CD4+ T cell that dampens the immune response.
16. Receptor on T cells that binds B7.
18. Molecule used by CTLs to poke holes in cell membranes targeted for apoptosis.
20. Cell death program triggered by CTLs.
22. Failure to respond to antigen due to lack of co-stimulation results in this process.
23. Co-stimulatory molecule on APCs that binds CD28.
24. ______ selection ensures T cells recognize self-MHC molecules.
28. _______ selection eliminates T cells that bind self-peptide too strongly.
30. An ___ cell is a T cell subtype that kills infected host cells.
31. Inability to distinguish self from nonself.
33. The ____ T cell subtype orchestrates immune responses using cytokines.
34. Receptor that deactivates an experienced T cell and is found on the same cell.
35. ______ describes rapid multiplication of antigen-specific lymphocytes.

2. Organ where T-cell education occurs.
3. Abbreviated name for cytotoxic T lymphocyte.
4. Process by which a cell engulfs and degrades extracellular material.
6. Cytokine produced by helper T cells that activates macrophages.
7. B cell tolerance mechanism involves editing their ______.
8. Protein expressed by repeatedly activated T cells that triggers apoptosis when bound to its cognate ligand.
9. MHC _____ is the requirement that TCR recognize both peptide and MHC.
11. node, Site where B cells form germinal centers.
14. 1, MHC class that presents endogenous peptides to cytotoxic T cells.
15. T cell subtype that suppresses excessive immune responses.
17. Cytokine that drives clonal expansion of activated T cells.
19. Cell type that displays antigen on MHC II to helper T cells.
21. The co-______ signal is the two-signal requirement that prevents inappropriate T-cell activation.
25. Short protein fragment bound in the groove of an MHC molecule.
26. The _____ antigen is recognized by a matching lymphocyte receptor.
27. Specialized blood vessel that allows lymphocytes to exit circulation. Abbreviation for high endothelial venule.
29. Cellular compartment where ingested proteins are degraded for MHC II loading.
32. Protein complex that presents peptide fragments on cell surfaces.