BHS316 Exam 2

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Across
  1. 7. positive selection; the process by which T cells are tested for recognition of self MHC molecules
  2. 9. enzyme released by CTLs that triggers apoptosis chain reaction inside cell
  3. 10. T cell activated by TGF-beta to produce TGF-beta and IL-10 to restrain the immune response
  4. 11. APC that travels to the lymph nodes to present antigens to naive T cells
  5. 12. when rearranged genes of the BCR can mutate to increase its affinity for its cognate antigen
  6. 13. this type of B cell activation requires crosslinking and co-stimulation from a foreign danger signal
  7. 15. cells in lymphoid follicles that display opsonized antigens to B cells
  8. 16. combination of gene segments that will produce a full-length Hc protein for BCR
  9. 21. special region in a small blood vessel where B and T cells can enter secondary lymphoid organs
  10. 24. the protein that removes CLIP and competes for binding on the MHC II molecule
  11. 25. the antibody that binds to mast cells to induce anaphylactic shock
  12. 26. cell that is activated by IL-12 and secretes TNF, IFN-gamma, and IL-2 for viral and bacterial attacks
  13. 28. only dendritic cells, B cells, and macrophages express this molecule, which binds CD4 and presents exogenous peptides
  14. 30. T cell protein that binds with B7 on an APC for co-stimulation
  15. 31. region of an antigen that is recognized by a BCR or TCR
  16. 33. proteins on the surface of NK cells that recognize "kill" or distress signals
  17. 34. cavity lined with macrophages that lymph first enters when it enters the lymph node
Down
  1. 1. protein that blocks the binding groove of MHC II molecules to prevent endogenous binding
  2. 2. protein released by CTLs to attack cell membrane for apoptosis
  3. 3. proteins on the surface of NK cells that recognize "don't kill" signals
  4. 4. cytoplasmic complex that cuts proteins into peptides
  5. 5. almost every cell expresses this molecule, which binds CD8 and presents endogenous peptides
  6. 6. when a cell is rendered non-functional after recognizing its cognate antigen but not receiving co-stimulation
  7. 8. the process by which T cells are tested for recognition of displayed self peptides
  8. 14. this type of B cell activation requires crosslinking and co-stimulation from a helper T cell
  9. 17. T cells that bind with self-antigens and suppress the activation of self-reactive T cells
  10. 18. where B and T cells are generated and B cells mature
  11. 19. cell that is activated by IL-4 to produce IL-4, IL-5, and IL-13 to defend against parasites or bacteria in the digestive tract
  12. 20. MALTs in the small intestines that utilize M cells
  13. 22. the main type of antibody B cells produced when first activated
  14. 23. cell that is activated by TGF-beta, IL-6, and IL-23 to produce IL-17, IL-21, and IL-23 to defend against fungi and extracellular bacteria
  15. 27. where T cells mature and receive self-tolerance training
  16. 28. the CD4 and CD8 molecules on T cells that help focus the cell's attention on othe proper MHC molecule
  17. 29. the main antibody that guards mucosal surfaces
  18. 32. when BCRs are clustered together they are: