Across
- 3. Secret location reachable by destroying rocks.
- 5. Female boss that dislikes smoke and leaves creep.
- 8. Tainted character that must manage two characters simultaneously.
- 9. Trinket that forces a boss to drop a specific item, formerly a "run killer" in Flash.
- 10. Item that causes all tears from Isaac's left eye to gain a special effect.
- 11. Active item that causes a high-damage, piercing laser attack, often associated with a biblical term.
Down
- 1. Edmund McMillen's original favorite character.
- 2. The character that was originally made for a 2001 Newgrounds cartoon.
- 4. Passive item that grants flight and +0.3 speed, often found in the Devil Room.
- 6. The name of Isaac's dad, whose initials are used in a hidden lore aspect.
- 7. The name of the arcade theme music in Rebirth, which refers to a bible verse.