BIO 202 Ch. 10 Crossword

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Across
  1. 3. ____ drugs are produced entirely by chemical reactions
  2. 4. bacteria may _____ digest the drug they have been treated with
  3. 8. ____ replicate/concentrate at the site of infection, whereas antibiotics are not centralized
  4. 12. _____ chemotherapy is the use of drugs to control infection
  5. 14. bacteria in ____ behave differently than when they are free-living; antibiotics often cannot penetrate ____
  6. 16. the goal of antimicrobial ____ is to administer a drug to an infected person that destroys the infective agent without harming the host's cells
  7. 17. _____ spectrum refers to antimicrobials effective against a wide variety of microbial types
  8. 18. this is the abbreviation for the smallest concentration of drug that visibly inhibits growth
  9. 20. ___ dilution is more sensitive and quantitative than the kirby-bauer test; allows for the determination of the minimum inhibitory concentration
  10. 21. bacteria may ___ out the drug they have been treated with
Down
  1. 1. the bacteriophage enzymes that lyse/kill bacteria
  2. 2. ____ cells are eukaryotic, present special problems in drug treatment; drugs designed to act on prokaryotes are ineffective against eukaryotes
  3. 3. drug _____ tests involve exposing a pure culture of the microbe to several different drugs and observing the effects of the drugs on growth
  4. 5. ___ TI indicates that the effective dose is close to the toxic dose, making it a more risky treatment
  5. 6. all-inclusive term for any antimicrobial drug, regardless of its origin
  6. 7. ___ index is the ratio of the dose of the drug that is toxic to humans compared to its minimum effective dosage
  7. 9. substances produced by the natural metabolic processes of some microorganisms that can inhibit or destroy other microorganisms
  8. 10. viruses may alter their ____ proteins, to avoid interaction with a protein targeting a drug
  9. 11. ____ spectrum refers to antimicrobials effective against a limited array of microbial types
  10. 13. ____ drugs are chemically modified in the laboratory after being isolated from natural resources
  11. 15. antimicrobial drug ____ is an adaptive response in which microorganisms begin to tolerate an amount of drug that would normally be inhibitory; can be from within as well as acquired
  12. 19. targeting the interruption of ____ sensing pathways has been a strategy to treat biofilms