Biomedical Innovations

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Across
  1. 5. Analyzes genetic and molecular data from individual cells
  2. 8. Adult cell reprogrammed into pluripotent state using transcription factors
  3. 12. Kohler helped invent the _________ technique for antibody production
  4. 13. Identical antibodies produced from a single B cell clone
  5. 14. Cech discovered self splicing introns in ___________ RNA
  6. 15. Can form nearly any cell type except supporting tissues
  7. 17. Found RNA component of RNase P performs catalysis
  8. 18. Modified 5 prime end structure that protects mRNA and aids translation
  9. 19. Conducted the first in vivo optogenetic stimulation in mice
  10. 20. Technique that separates charged molecules in a gel under an electric field
  11. 22. Used restriction enzymes to create genetic maps of viruses
  12. 27. Bacterial enzymes that cut DNA at specific recognition sequences
  13. 29. Imaging technique using radioactive decay to expose film and visualize samples
  14. 31. Digital autoradiography using phosphor screens to quantify radiation
  15. 33. Demonstrated stem cells in mouse spleen colony assays
  16. 34. Reprogrammed adult fibroblasts into induced pluripotent stem cells
  17. 35. Scientist who discovered the poly A tail
Down
  1. 1. Developed the Butterfly IQ imaging system
  2. 2. Process removing cells from tissues to leave extracellular matrix scaffold
  3. 3. Macugen is a ________ inhibiting drug
  4. 4. Co developed fluorescence activated cell sorting technology
  5. 6. Light activated ion channel that excites neurons
  6. 7. Separates mixtures based on component affinity for stationary versus mobile phase
  7. 9. ____________ Counting detects beta particles by converting emissions into measurable light flashes
  8. 10. In vitro selection method that isolates high affinity nucleic acid aptamers
  9. 11. Catalytic RNA molecules that can splice or cleave RNA
  10. 16. Protein detection method using antibodies after gel electrophoresis
  11. 21. Light driven chloride pump that silences neurons
  12. 23. Detects specific DNA fragments via hybridization on a membrane
  13. 24. Can form every cell type including supporting tissues
  14. 25. Conceived the polymerase chain reaction
  15. 26. Developed standardized decellularization methods for tissue engineering
  16. 28. Isolated and characterized the first restriction enzyme
  17. 30. Technique that exponentially amplifies DNA through repeated temperature cycling
  18. 32. Technique using light controlled ion channels to manipulate neurons