BMS1 Pharmacology

4. VGSCs are activated by this
8. Lipids catabolized downstream of Gq activation
11. Lipid-soluble drugs cross this to activate nuclear receptors
13. Main kinase activated through cytokine receptors
16. Ligand-gated ion channel activated by acetylcholine
17. Measure of the maximal effect produced by a drug-receptor interaction at plateau
19. Drug receptor category of cyclooxygenase
20. concentration of drug required to produce an effect of a given intensity
21. Signals using G proteins

1. study of adverse effects of substances on living systems
2. index measure or the ratio between a toxic and efficacious doses
3. process tying drug binding to the end effect observed
5. Term for not binding outside of the orthosteric site
6. Antagonist that blocks agonist activity by binding to the orthosteric site
7. Description for the total amount of receptors bound at plateau
9. Drug receptor category of SERT
10. Ion channel state where ions are flowing through the channel
12. GPCR activated by acetylcholine
14. Agonist that produces a submaximal maximal response when all receptors are occupied
15. measure of the strength and probability that a drug will bind an available receptor
18. Activated by adenylyl cyclase