Bones

3. Type I ___ is a key component of the bone organic matrix
6. Chronically elevated phosphate levels lead to ___ hyperparathyroidism in renal disease patients
7. Approximately 50% of plasma calcium is found in the ___ (ionized) form
8. Spectrophotometric methods based on metallochromic dyes are commonly used for measuring ___ calcium
10. Hypocalcemia can result from ___ mutations of the CaSR
11. ‘Bones, Stones, Groans, Thrones, and Psychic Moans’ are symptoms of ___
12. Free calcium levels in plasma are tightly regulated by ___ hormone
16. Anticoagulant in whole blood specimens for free calcium measurement
17. After parathyroidectomy, the drop in PTH may lead to ___ bone syndrome
18. Cell type responsible for bone formation
19. A cytokine that acts as a decoy receptor for the RANK-RANKL interaction, inhibiting maturation of osteoclasts
20. A decrease in pH will lead to an ___ in the free calcium

1. Bone contains about 55% of the body content of this mineral
2. Cell type responsible for bone resorption
4. Increased levels of ___ lead to decreased plasma phosphate levels by promoting renal phosphate excretion and decreasing production of calcitriol
5. Most common cause of apparent hypocalcemia in hospitalized patients
9. Disease of low bone mass and porous bone when a remodeling imbalance favors resorption
13. Growth plate fusion, aka ___ closure, occurs at the end of puberty
14. Product of 25-OH Vitamin D activation in the kidneys
15. Massive transfusion of ___ blood products can cause hypocalcemia