Breast Cancer Genetics

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Across
  1. 3. Individuals carrying a harmful BRCA variant are at increased risk of developing breast, ovarian, pancreatic and ________ cancer. (8)
  2. 4. Tumour __________ genes regulate cell growth. (10)
  3. 5. Breast cancer risk in women with one affected first-degree relative is ______ that of women with no affected first-degree relative. (6)
  4. 7. Carriers of harmful BRCA variants have an increased risk of developing _____________ breast cancer in the years following diagnosis. (8)
  5. 10. BRCA variant carriers have a _______ percent chance of developing breast cancer by age 80. (7)
  6. 11. BRCA mutations result in genetic ___________. (11)
Down
  1. 1. BRCA mutations are inherited in an autosomal ________ fashion. (8)
  2. 2. Which DNA damage response process do the BRCA genes function in? (10, 13)
  3. 6. Inheritance of a mutation in one of the ____ genes is the greatest risk factor for breast and ovarian cancer. (4)
  4. 8. Between 5 and ___ percent of breast cancers are thought to be inherited. (3)
  5. 9. Germline mutations in the BRCA genes result in __________ breast and ovarian cancer syndrome. (10)