CANCER

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Across
  1. 1. inhibit cell growth through the physical
  2. 3. Clinically evident when cells reach a ____
  3. 4. indiscriminate and continuous
  4. 7. development of own blood supply
  5. 8. continues to function until it degenerates
  6. 11. cells can be perceived as nonself and elicit an immune response resulting in their rejection and destruction
  7. 15. Role of the____
  8. 17. tumor limited to the tissue of origin; localized tumor____
  9. 18. extensive____and regional spread
  10. 19. of genes that control differentiation and proliferation
  11. 20. respect the boundaries and territory of the cells
  12. 21. Will not invade a ____that is not their own
  13. 23. Staging of cancer gives a____about aggressive spread of tumor in body
  14. 26. Based on the____ extent of disease rather than on cell appearance
  15. 27. Cancer cells can be____ as nonself and elicit an immune response resulting in their rejection and destruction
  16. 29. important regulators of normal cell process which promotes growth
  17. 32. Most___contain undifferentiated cells =stem cells
  18. 33. rapid-response cells attack viruses and may also be aggressive in attacking cancerous pre-cancerous cells
  19. 35. Involves a mutation in the cell’s genetic structure
  20. 39. limited local____
  21. 40. that is 1.0 cm (0.4 inch) (the size usually detectable by palpation) contains 1 billion cancer cells
  22. 42. Ability of___cells to invade and metastasize -major difference between benign and malignant neoplasms
  23. 43. Extent of____
  24. 44. multistep process beginning with the rapid growth of the primary tumor
  25. 45. them
  26. 46. Second stage where the transformed cells are stimulated to divid
  27. 47. short-lived cells are the first line of defense against infection; kills bacteria, then die, forming pus
  28. 48. and detect and destroy cells with abnormal or altered antigenic determinants
Down
  1. 2. Cells are ____ and primitive and undifferentiated; cell of origin is difficult to
  2. 4. Third stage where tumor cells compete with one another to survive, leading to more mutations that make the
  3. 5. As the tumor increases in, the cells undergo further mutations
  4. 6. Not complete until all ___are done on tumor
  5. 8. produce histamines that help the immune system attack allergens
  6. 9. Can be clinical and ____
  7. 10. may involve one or more cellular changes that are either spontaneous or started by exposure to a_____
  8. 12. immune system’s response to antigens of the malignant cells where lymphocytes continuously check cell-surface
  9. 13. develop and mature in the bone marrow and make proteins called antibodies that fight viruses and bacteria
  10. 14. divides into two identical cells
  11. 16. also form in bone marrow but mature in the thymus has two main types: helper T-cells that stimulate B-cells to make antibodies, and killer T-cells that attack cells directly
  12. 22. Produce more than two cells at the time of mitosis
  13. 24. All cells have the___ to perform all body functions
  14. 25. transformation may involve more than one step and requires repeated exposures to promoting agents
  15. 28. function to regulate cell growth
  16. 30. an orderly process that progresses from a state of immaturity to a state of maturity
  17. 31. termed tumor-associated antigens (TAAs)
  18. 34. more aggressive
  19. 36. cells innate immune system's traffic cops, directing T-cells and B-cells to their targets
  20. 37. Greek words that mean “big eaters,” these long-limbed that are voracious, using flexible tendrils to snag and attack their targets
  21. 38. Staging applied to specific____
  22. 41. As cells ____, this potential is repressed, and the mature cell is capable of performing only specific functions