Across
- 3. MOA-delivers diphtheria toxin and IL2 to cells expressing IL2 receptor (CD 25)
- 4. Binds to BCR-ABL to prevent unregulated cell growth/proliferation
- 6. Indicated for Relapsed/refractory T-Cell Lymphoma, Side effects include QT prolongation and SJS rash
- 8. CBC weekly for first month then biweekly for the second month
- 10. Is an VEGF inhibitor that blocks angiogenesis and should be held for 28 days prior to surgery and restarted 28 days later.
- 13. VEGF Inhibitor that Inhibits angiogenesis and can lead to hemorrhage
- 16. blocks activity at the 26S proteasome, leading to inhibition of cell growth
- 19. Inhibits EGFR and HER2 tyrosine kinase, ultimately leading to cell death
- 20. mTor inhibitor that should be used in caution with bilirubin > 1.5x ULN
- 22. this ia a Poly ADP-ribose polymerase inhibitor (PARP)
- 23. Side effects include rhabdo
Down
- 1. MOA-HSV-1 virus that lyses tumor cells
- 2. Side effects include taste changes, QT prolongation and pulmonary embolism.
- 5. moa-is a CDK 4 and 6 inhibitor
- 7. Side effects include the reactivation of Hep B and tumor lysis syndrome which can lead to renal failure.
- 9. Monitor for LVEF at baseline or every 3 months, s/sx of pulmonary/cardio toxicity
- 11. monitor serum electrolytes periodically, and pregnancy test 1 week prior to tx
- 12. irreversible inhibitor of 20S proteasome, Side effects include acute liver failure.
- 14. Indicated for NSCLC and pancreatic cancer, PPI’s and H2s can decrease absorption
- 15. indicated for Multiple Myeloma after 2 failed tx’s
- 17. Side effects include T2DM new onset, hypercholesterolemia, TG ↑
- 18. Monitor serum Mg++, K+, and Ca++ levels every 8 weeks
- 21. Inhibits delta Phosphatidylinositol 3-kinase (PI3K-delta)
- 24. reversibly inhibits beta 5 subunit of 20S proteasome, side effects include blurred vision, thrombocytopenia, neutropenia, and conjunctivitis.