Cancer Tumour Progression

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Across
  1. 5. Part of how Cancer cells invade other tissues is loss of ____ to other cells and the ECM
  2. 6. assessment of tumour tool that tumour size and invasiveness, regional lymph node involvement and metastasis
  3. 7. Extracellular Matrix
  4. 8. Tumour stage with blood-borne metastasis
  5. 9. Paget’s hypothesis that its carried in all directions but only grows where it’s possible/easiest
  6. 10. stage of a tumour with a small tumour and no spread
  7. 12. type of tissue that are non-epithelial and more loosely organized, found within organs and bones
  8. 15. Upregulation of ____ that digest proteins leads to breakdown of the ECM
  9. 16. immature Cell able to give rise to other cells
Down
  1. 1. process of arresting cell growth when cells come in contact with each other that is lost in cancer cells
  2. 2. separates epithelial cells from adjacent connective tissue
  3. 3. _____ cells are normally found in connective tissue and are spindle-shaped, more migratory and lack apical basal polarity.
  4. 4. Tissues that are non-epithelial found with organs
  5. 7. Cancer cells migrate out of the bloodstream and invade tissue/organs
  6. 11. Through experiments with mice cancer cells potential for metastasis was found to express _____
  7. 13. Anagram for the process of epithelial cells becoming more like mesenchymal cells which happens in wound healing or from oncogene growth signalling.
  8. 14. Locally invasive cancer cells becoming more enters a local blood vessel