Across
- 4. Chronic ______ disease (CGD) is caused by genetic defects that alter enzymes and proteins involved in neutrophil production of reactive oxygen species (by NADPH oxidase) to kill bacteria
- 7. _____ granules stain a dark bluish color. They are lysosomes that usually contain acid hydrolase enzymes. Common to ALL types of leukocytes
- 10. matrix _______ are enzymes that allow neutrophils to travel through connective tissue
- 14. Granules of _____ contain several factors specifically directed against parasitic worms and protozoans
- 16. aka MPO enzyme system, contained within some azurophilic granules. Convert peroxides into bacteria-destroying hypochlorous acid --> metabolized into hypochlorite (BLEACH!) and chlorine
- 17. natural ____ lymphocytes directly kill virally infected cells. But they do not need to recognize MHC I complexes on a target cell to do so
- 20. Platelets are also known as ______
- 21. Platelets are particularly sensitive, and readily adhere to exposed _______ (protein)
- 22. After ejecting its nucleus, this RBC precursor cell still retains a small amount of ribosomes (only a methylene blue stain will show the ribosomes)
- 23. B lymphocytes develop into _____ cells following activation
Down
- 1. The most common type of leukocyte in the blood are _____. They have a multi-lobed nucleus and secretory granules (that stain poorly), so the lobed nucleus is the most prominent feature of this cell type
- 2. (often) branched cytoplasmic processes that megakaryocytes extend towards vascular sinusoids when producing platelets
- 3. B and T _____ are the only cells able to recognize specific epitopes
- 5. aka white blood cells. They are nucleated and born in the bone marrow. Divided into granulocytes and agranulocytes
- 6. ______ erythroblasts are RBC precursor cells that have not yet ejected their nuclei
- 8. aka granulomere; the inner region of a platelet where darkly-staining organelles and granules are located
- 9. The branch of leukocytes that include neutrophils, eosinophils, and basophils. They have multi-lobed nuclei and contain numerous secretory granules in their cytoplasms
- 11. The developmental stage just prior to a mature neutrophil is known as a band cell or ____ cell. Has elongated nucleus
- 12. Granules of _____ contain heparin, histamine, and leukotriene, which are also released by mast cells
- 13. _____ granules have special functions and stain differently for each type of granulocyte
- 15. The outer, lightly staining portion area of a platelet; contains highly glycosylated plasma membrane, ring of microtubules for shape, and a system of actin and myosin filaments
- 16. Platelets are produced by specialized cells in the bone marrow called ______
- 18. _____ are the precursor cells to macrophages. They exert no effects while in the blood
- 19. T cells become _____ T cells after activation (or T memory cells)