Cell Bio Proteins Midterm 2

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Across
  1. 4. / Promotes actin polymerization by changing G-ADP --> G-ATP
  2. 8. / Microtubules plus end directed motor protein
  3. 9. / Network proteins that is found in the leading edge, stress fibres, and filopodia. It can bind to actin to create more crosslinks
  4. 14. / binds to contractile bundles to connect the plasma membrane and the extracellular matrix.
  5. 17. / Caps the minus end of an actin molecule
  6. 19. / Formed around the sarcomere in muscle cells. Links muscle cells together
  7. 20. / Linked to tropomyosin. Will undergo a conformational change when bound to calcium
  8. 23. / Protein complex that actives Arp2/3
  9. 26. / Important for tissue integrity and holding cells together
  10. 27. / Contains 2 heavy chains and is involved in anterograde transport
  11. 28. / is polymerized from G-actin
  12. 30. / Binds spectrin to the plasma membrane. Also thus binds the cytoskeleton to the membrane as well. Can bind vimentin and link it to the cytoskeleton
  13. 32. / needed for retrograde transport. Composed of 2 heavy chains and 2 head domains that work together to walk towards the minus end. Uses the dynactin hetero complex to bind to cargo.
  14. 34. / regulator that sequesters G-actin and provides a reservoir
  15. 37. / Links the actin cytoskeleton to transmembrane proteins. It is important for red blood cells.
  16. 39. / Heavy chain that binds to the microtubule and is simply used to carry things
  17. 40. / Involved in muscle contractions. Forms a thick filament in between actin filaments
  18. 41. / Holds myosin in place in the sarcomere
  19. 44. contains 2 heavy chains and 2 light chains. It is involved in anterograde transport and is the
  20. 45. / Cdc42, Rac, and Rho
  21. 46. / Depolymerizes when added to actin
  22. 48. / Expressed in mesenchymal cells. (Migrating Cell)
  23. 49. / composed of four domains and an ATP binding cleft
Down
  1. 1. / A nucleating agent that regulates the plus end of actin (Speed). It assembles unbranched filaments. Regulated by Rho-GTP
  2. 2. / Protein that forms bundles by adjoining parallel actin microfilaments. Located in stress fibres, filopodia, and the muscle Z line.
  3. 3. / Main constituent of microtubules in the cell
  4. 5. / Protein that forms bundles by adjoining parallel actin microfilaments. Located in microvilli, filopodia and focal adhesions.
  5. 6. / Involved in organelle trafficking. Composed of 2 heavy chains with many light chains to carry cargo
  6. 7. / Binds to actin to create more crosslinks and crossbridging. Located in the cell cortex
  7. 10. / Coats actin so that the myosin binding site is covered preventing myosin from binding to actin
  8. 11. / provides lateral cohesion and a smooth end to the microtubule
  9. 12. abundant of it's kind
  10. 13. / Protein complex that activated WASp
  11. 15. / Protein complex that activates WAVE
  12. 16. / found in neurons. In axons and dendrites because you want them to be strong (Will give them great tensile strength)
  13. 18. / Links dynein to the dynactin heater complex. Too much or too little will inhibit transport
  14. 21. / Links actin to transmembrane proteins in microvilli
  15. 22. / Minus end capping protein
  16. 24. / Link intermediate associated proteins to microtubules
  17. 25. / Found in all cells to help hold the nuclei shape. Has a Linc complex to connect it to cytoskeletal components
  18. 29. / Plus end directed motor that can like the actin network to the plasma membrane. Plays a role in endocytosis
  19. 30. / Permanently linked to the A tubule, generates bending through movement along the microtubule towards the minus end
  20. 31. / Involved in the MTOC and it's ring complex provides nucleating sites for microtubules
  21. 33. / Regulates the plus end and mediates filament branchingg
  22. 35. / Protein complex that actives Arp2/3 and is regulates by Rac
  23. 36. Myosin / Coats the microfilament so it will not readily depolymerize. Forms on arrowhead on actin that points towards the minus end
  24. 38. / provides a link from the actin cytoskeleton to the extracellular matrix.
  25. 42. / Invovled in relative sliding. Forms a bipolar structure composed of 4 heavy chains (2 heads/side)
  26. 43. / Main role is to pull dimers off the plus end of a microtubule. (Depolymerization)
  27. 47. / When there is no tension at the metaphase plate between the MT and the chromosomes, this will be phosphorylated.This causes the MT to release the chromosomes giving it the ability to capture them from both sides again.
  28. 50. / caps the plus end of an actin molecule
  29. 51. / forms a ladder like structure that binds doublets together in the axoneme