Cells of the Innate Immune System

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Across
  1. 7. proteins that inhibit growth of bacteria by binding to iron
  2. 8. cytokines that alter the hypothalamic thermostat, causing fever
  3. 10. phagocytes that exist in the blood and mature into macrophages in response to chemokines
  4. 13. proteins that kill microbes and attract dendritic cells and mast cells
  5. 14. cells that engulf foreign microbes and debris via their cell membrane
  6. 15. cells that release potent inflammatory mediators (including histamine, cytokines, prostaglandins, leukotrienes, and complement)
Down
  1. 1. the system that results in opsonization of pathogens, a membrane attack complex that kills bacteria, and inflammation
  2. 2. natural killer cells that are pro-inflammatory cytokines that activate cells and affect viral infections (hint:and in the word)
  3. 3. leukocyte that becomes phagocytic when it encounters infectious material (not present in healthy tissue, major component of pus)
  4. 4. inactivate proteins in plasma that complement antibacterial activity in the body
  5. 5. phagocytes that "eat" (can be tissue resident or be made in response to inflammation)
  6. 6. highly specialized phagocytes that are also antigen-presenting cells, linking the innate and adaptive immune system
  7. 7. small secreted proteins that interfere with viral replication
  8. 9. large granular lymphocyte defensive cells found in the blood and tissues
  9. 11. natural killer cell that enters the cell and causes apoptosis
  10. 12. natural killer cell that makes a hole in the cell