Across
- 3. Immature/unactivated B or T cells before they encounter their specific antigen.
- 4. Artificial active immunization that introduces selected antigens to stimulate a primary response and memory cells.
- 6. Smallest white blood cells (20-40% of leukocytes) that are the key players in adaptive immunity; include B cells and T cells.
- 7. Host cell surface proteins (MHC I or MHC II) that display antigen fragments for T cell recognition (antigen presentation).
- 9. Adaptive immune response involving antibodies produced by B cells that defend against extracellular pathogens in body fluids.
- 12. T cells (Tregs) that modulate/suppress the immune response to prevent excessive inflammation.
- 13. (cells) Long-lived B or T cells that "record" information to provide a faster response if the same pathogen returns.
- 15. Soluble form of the B cell receptor (also called immunoglobulin) secreted by plasma cells to defend against pathogens in body fluids.
Down
- 1. Historical immunization method using dried smallpox material (predecessor to modern vaccination).
- 2. Substance that can elicit a response from a B or T cell.
- 5. Cells (e.g., B cells, macrophages, dendritic cells) that process and present antigen fragments on MHC to T cells.
- 8. T cells (TH cells, often CD4+) that act as "conductors," activating other immune cells including B cells.
- 10. (cells) Differentiated B cells that actively secrete antibodies (humoral response).
- 11. T cells (TC or CTL, often CD8+) that directly kill infected or abnormal cells.
- 14. Small accessible part of an antigen that binds to an antigen receptor.