Ch. 13 Sterile and Hazardous Compounding

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Across
  1. 5. A permanent, patient- or batch-specific document that details the actual preparation of a compounded product, including ingredients, lot numbers, amounts, equipment, dates, and the person who prepared and verified it.
  2. 12. Solution- A sterile parenteral product in a container typically 100 mL or less (e.g., 50 mL or 100 mL minibags, vials, ampules) used for intermittent infusions or admixtures.
  3. 13. A drug or agent that prevents or inhibits the growth of malignant cells and is used in chemotherapy to treat cancer.
  4. 14. Vial- A vial that contains more than one dose of medication and includes a preservative; it can be entered multiple times within a defined beyond-use date.
  5. 15. compatibility- The ability of two or more substances (e.g., a drug and an IV solution or container) to be mixed or stored together without reacting, degrading, precipitating, or forming harmful products.
  6. 16. The movement of water across a semipermeable membrane from a region of lower solute concentration to a region of higher solute concentration until equilibrium is approached.
  7. 19. A sterile liquid (such as normal saline or sterile water) used to reconstitute a powder or dilute a drug to the desired concentration or volume.
  8. 21. A specialized area of pharmacy that prepares, handles, and dispenses radiopharmaceuticals containing radioactive isotopes for diagnostic imaging and therapy, under strict radiation-safety and sterile-compounding standards.
  9. 22. The total number of osmotic particles per liter of solution, typically expressed as milliosmoles per liter (mOsm/L), reflecting solute concentration in a volume of fluid.
  10. 26. The process of filling IV tubing or a filter set with fluid before connecting it to a patient, which removes air from the line and wets all internal surfaces.
  11. 27. IV Line- An intravenous catheter inserted into a small peripheral vein (typically in the hand or arm) used for short-term or less-concentrated IV fluids and medications.
  12. 28. A needle that contains a small in-line filter, used when withdrawing medication from glass ampules or suspensions to remove glass shards or particulate matter.
Down
  1. 1. Vial- A vial intended for one-time use that does not contain preservatives and must be discarded after a single puncture or within a short time per guidelines.
  2. 2. A technique used when withdrawing medication (especially hazardous drugs) from a vial in which slightly less air is injected than the volume withdrawn so that internal vial pressure is lower than atmospheric, minimizing aerosolization or leakage.
  3. 3. A sterile 0.9% sodium chloride solution in water that is approximately isotonic with blood and commonly used as an IV fluid and drug diluent.
  4. 4. A chemical added to multi-dose drug products to inhibit microbial growth and extend the product’s usable life after first puncture.
  5. 6. A numeric scale (0–14) that indicates how acidic or basic a solution is, with 7 being neutral, lower values acidic, and higher values basic; important for drug stability and compatibility.
  6. 7. The number of drops per milliliter delivered by an IV tubing set (e.g., 10 gtt/mL, 60 gtt/mL), used to calculate manual IV flow rates.
  7. 8. A specific quantity of a drug or product made in one manufacturing run under the same conditions, intended to have uniform quality and characteristics.
  8. 9. A one-handed technique for recapping needles in which the cap is placed on a flat surface and the needle tip is “scooped” into the cap, reducing the risk of needlestick injury.
  9. 10. A prepared set of materials (e.g., absorbent pads, PPE, neutralizing or deactivating agents, disposal bags) used to safely contain, clean, and dispose of hazardous drug or chemical spills.
  10. 11. The speed at which IV fluid or medication is administered, commonly expressed in mL/hour or, for some drugs, in units such as mcg/kg/min.
  11. 16. Pressure- The pressure that must be applied to a solution to prevent the net movement of water by osmosis; it reflects the solution’s tendency to draw water across a semipermeable membrane.
  12. 17. Nutrition- A parenteral nutrition formula given through a peripheral vein, formulated with lower osmolarity than central TPN to reduce vein irritation and used for short-term or partial nutritional support
  13. 18. A description of a solution’s effective osmotic pressure relative to body fluids, classified as isotonic, hypotonic, or hypertonic, which predicts fluid shifts across cell membranes.
  14. 20. A scored or weakened ring around the neck of certain ampules or vials that indicates where the glass should be broken to open the container.
  15. 22. The extra volume of solution intentionally added by manufacturers to IV containers to ensure the labeled volume can be withdrawn and to account for tubing and container losses.
  16. 23. A sealed glass container that holds a sterile injectable solution, opened by snapping the neck at a scored line and always accessed with a filter needle to avoid glass particles.
  17. 24. A technique for withdrawing solution from a vial under pressure by alternately adding small amounts of air and withdrawing fluid in small increments to maintain control and reduce spray or coring.
  18. 25. Parenteral- A sterile IV solution in a container typically greater than 100 mL (commonly 250–1000 mL), such as 0.9% sodium chloride or dextrose solutions used for hydration and continuous infusions.