Across
- 5. First permanent settlement in the United States
- 9. Early Spanish explorers
- 12. Resistance to a disease
- 14. Valuable goods from the Indies sought after by European traders
- 16. Religious movement started by Martin Luther
- 18. Town or trading center
- 19. Economic theory that bases a nation's power on its wealth
- 21. Island chain where Columbus first landed
- 22. Queen of Spain that agreed to pay for Columbus's expedition
Down
- 1. Sailed west across the Atlantic Ocean to find a sea route to Asia
- 2. Religious community
- 3. Fort, usually built near a mission
- 4. Dutch explorer that discovered a river and a bay
- 6. Spanish explorer who landed on the coast of Florida
- 7. Island where New Amsterdam was built
- 8. Used by sailors to find their location at sea using the stars
- 9. Conquistador that conquered the Aztec Empire in Mexico
- 10. Spanish war fleet
- 11. The islands southeast of Asia
- 13. First name of an Italian explorer that is namesake of the Americas
- 15. New form of Christianity that opposed the Catholic Church
- 17. Used by sailors to tell which direction they were sailing
- 20. Conquistador that conquered the Inca Empire in Peru