Across
- 1. antimicrobial substances that function like locally produced endogenous antibiotics
- 7. immunity in which T cells play a major role and which provides defense against infections by intracellular microbes (no need to write the word ‘immunity’)
- 9. signature cytokine produced by Th1 cells (abbreviation)
- 10. integrin that firmly holds the two cells together, forming an immune synapse into which the CTLs secrete cytotoxic proteins
- 11. cells that are induced in parasitic worm infections and promote IgE-, mast cell- and eosinophil-mediated destruction of the parasites (no need to write the word ‘cells’)
- 12. t cells that are long-lived and functionally inactive and are ready to respond rapidly to repeated exposure to the same microbe.
- 15. ligand present on T cells that helps in activation of macrophages and APCs to secrete more cytokines and express more costimulators
Down
- 2. t cells that are generated after the process of differentiation and their main function is to eliminate microbes
- 3. lymphoid organs where naïve T cells are stimulated by microbial antigens (this is an umbrella term)
- 4. granule protein secreted by CTLs that cleaves and thus activates caspases
- 5. substance secreted by CTLs that disrupts the integrity of the target cell plasma membrane and endosomal membranes
- 6. inhibitory receptor present on T cells
- 8. cytokine that is required for the survival and function of regulatory T cells
- 13. type of macrophage that are activated by Th1 cells (no need for the word ‘macrophage’)
- 14. receptor on T cells that recognize B7 costimulators on APCs (no need to use the word ‘receptor’)