Cicatricial eye disease

2. used to diagnose limbal stem cell deficiency (10, 8)
3. scoring system to calculate severity of SJS/TEN
6. always consider in unilateral cicatrising conjunctivitis, particularly in elderly
9. device used to prevent symblepharon in acute SJS/TEN
10. Cicatrising, blinding disease not endemic in the UK, associated with poor access to water and sanitation
12. common, often epidemic infectious cause of cicatrisation (10, 14)
14. physical type of injury that can cause cicatrisation
16. class of drugs that help reduce ocular surface inflammation by inhibiting matrix metalloproteases
17. treatment option in refractory end-stage cases with severe corneal opacification/keratinisation (6,4)
19. tissue graft used to reconstruct fornix in OCP (4, 6)
20. Stage 3 of Foster's classification of OCP
21. flattened in cicatricial disease
22. first line immunomodulatory therapy in severe OCP

1. inherited cause of cicatricial disease also affecting hair and teeth (10, 9)
4. biological corneal bandage containing amniotic membrane, can be applied in clinic
5. chemical burn classification system with 4 grades (5,4)
7. Stage 1 of Foster's classification of OCP (15, 8)
8. shortened in cicatricial disease
10. Eyelash abnormality that develops as OCP progresses
11. drug that causes SJS
13. transplant procedure that can later lead to ocular surface inflammation with cicatrisation (4, 6)
15. Topical antimicrobial that can cause cicatrisation
18. Common condition that can cause cicatrisation, patient may report intermittent facial flushing and redness