Clinical Immunology Crossword 09/23/25

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Across
  1. 5. vaccinating the majority reduces infections in unimmunized people
  2. 8. Hypersensitivity reaction mediated by TH2, IgE, and Mast Cells
  3. 9. Medication class that suppresses pro-inflammatory cytokines and prostaglandins.
  4. 11. deletion of autoreactive lymphocytes during development
  5. 14. One of the mechanisms NK cells use to kill diseased/target cells, involving CD16
  6. 16. Suppression of autoreactive lymphocytes in peripheral tissues
  7. 18. Tissue transplantation within the same body
  8. 19. type of immunosupressive therapy that that attempts to prevent early acute rejection
  9. 21. Chronic Type 1 Hypersensitivity disease
  10. 22. TLR9 agonist and vaccine adjuvant, resulting in DC activation and cytokine production
  11. 26. a vaccine type aimed at the "prevention" of a disease
  12. 27. STAT3, AP1, and NFkB are examples of this category of gene implicated in cancer
  13. 28. this type of vaccine may be produced by recombinant DNA technology
Down
  1. 1. pro-inflammatory lipid mediators that function in leukocyte recruitment, bronchoconstriction and vasodilation
  2. 2. Determines organ compatibility by measuring T cell reactivity to donor cells
  3. 3. Term for donor T cells attacking host T cells. (Bone marrow/ stem cell)
  4. 4. type of graft rejection occurring 24hrs after transplant
  5. 6. tissue transplantation between different species
  6. 7. uncontrolled proliferation of abnormal cells due to mutations in genes regulating cell growth and survival.
  7. 10. A mutation in this gene results in autoreactive T cells that attacks endocrine glands
  8. 12. p53 and PTEN are examples of this category of gene implicated in cancer
  9. 13. set of MHC genes inherited together from one parent.
  10. 14. transplant between same species
  11. 15. Prophylactic vaccine used to prevent maternal sensitization to fetal blood
  12. 17. Anti-Rh IgG prophylaxis
  13. 20. relieves itching, hives, mild symptoms of allergic reactions
  14. 21. substances added to vaccines improve immune responses against antigens
  15. 23. Hypersensitivity reaction mediated by TH1 cells and macrophages
  16. 24. reactions that are adaptive immune responses against allergens or self antigens
  17. 25. What type of vaccine is used when bacterial toxins cause disease