Clostridium Difficile

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Across
  1. 3. These types of antibodies are utilized through passive immunization as an adaptive response in immunotherapy. Of importance, Bezlotoxumab
  2. 4. A major risk factor amongst CDI is this type of medication treatment
  3. 5. A type of immune response accompanied by IgG, IgM and IgA antibodies utilized in the protection against infection
  4. 8. As new research is conducted, ____ are in development to provide active immunity
  5. 9. The sig for “by mouth.” This is a route of administration in which antibiotic treatments are supposed to be taken
  6. 10. Decreased amounts of this bacteria has demonstrated Clostridium Difficile reoccurrence
  7. 12. This is a major challenge, involving approximately 15% to 25% of cases 60 days following the first infection
  8. 16. Pseudomembranous colitis is identified by this damage on the tissue of the colon
  9. 18. This motile appendage allows for the Clostridium Difficile to colonize the colon
  10. 19. In terms of children, the bacteria is present in the ages of 1 to ___ years old.
  11. 20. This is the main granulocyte present at the site of inflammation, most abundant in the body
  12. 22. This bacterial infection is normally present in individuals above this age
  13. 24. This type of regulation element could lead to gene expressions of toxins and flagella maintenance
  14. 26. This is an inhibitory germination component
  15. 28. This is a form of genotypic ribotyping in order to type Clostridium Difficile and is commonly used as an amplification technique within conserved regions
Down
  1. 1. Historically this has been the drug of reference for Clostridium Difficile treatment
  2. 2. Both Toxin A and B are involved in the stimulation of ____ and chemokines which determined the severity
  3. 6. A characterization associated with CDI leading to a body weight that is lower than normal
  4. 7. New evidence has demonstrated infants who are breast fed are less likely to have colonization of the bacteria possibly due the ___ antibody in breast milk.
  5. 11. When Toxin B is present in great concentration, it is able to produce reactive oxygen species
  6. 13. Both IgG and IgA counteract toxins and are of high ____
  7. 14. In this stage, these cells are capable of producing Toxin A and B
  8. 15. The promotion of germination in Clostridium Difficile is conducted by this primary component, following cholate.
  9. 17. In the diagnosis of Clostridium Difficile, a two-step testing technique is utilized consisting of a sensitive and toxin exam
  10. 21. New evidence has supported the use of this antibiotic as it has high efficacy
  11. 23. A new type of therapy where a distinct microbiome is reintroduced into the colon in order to reinstate colonization resistance
  12. 25. The epidemiology of the bacteria and its various ribotypes is present all over the world including North America, South American, Eastern Europe even parts of Asia.
  13. 27. A 017 RT toxin emerging from ____ and creates a tcdB toxin, where the tcdA gene is nonfunctional due to deletion