CNS - Opiods

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Across
  1. 2. A highly potent synthetic opioid, often used in patches or IV anesthesia, notorious for its role in overdoses
  2. 3. A common and persistent adverse effect of chronic opioid use caused by decreased GI motility
  3. 5. A synthetic opioid agonist commonly used in maintenance therapy for opioid use disorder because of its long duration of action
  4. 7. A mixed agonist-antagonist or partial agonist used to treat opioid dependence due to its long half-life and ceiling effect
  5. 9. An ultra-short-acting synthetic opioid rapidly metabolized by non-specific tissue esterases
  6. 10. The classic prototype strong opioid agonist derived from the poppy plant
Down
  1. 1. Competitive opioid receptor antagonist used to rapidly reverse acute opioid overdose
  2. 4. The structural component or core found in classical opioids like morphine and codeine
  3. 6. An antitussive opioid drug that requires metabolic conversion by CYP2D6 into morphine to exert significant analgesia
  4. 8. A classic sign of opioid toxicity characterized by pinpoint pupil