Across
- 4. Exchange of goods, plants, animals, and diseases between the Old and New Worlds
- 6. Spanish monarchs who funded Columbus’s voyages
- 7. Indigenous people of the Caribbean who encountered Columbus
- 8. Italian city, birthplace of Christopher Columbus
- 11. Luther's 1517 document challenging the Catholic Church
- 13. Explorer who sailed across the Atlantic in 1492
- 14. Last emperor of the Aztecs, killed during the Spanish conquest
- 17. The name of the Aztecs, their own term for themselves
- 19. Venetian explorer whose travels to Asia were recorded in "The Travels"
- 20. Spanish explorers who conquered large parts of the Americas
- 21. Island in the Caribbean where Columbus first landed
Down
- 1. German monk who initiated the Protestant Reformation
- 2. Spanish explorer who crossed the Isthmus of Panama and was the first European to see the Pacific Ocean
- 3. French theologian who played a key role in Protestantism
- 5. Spanish conquistador who led the expedition that caused the fall of the Aztec Empire
- 9. English sea captain who circumnavigated the globe and defeated the Spanish Armada
- 10. First European city-state to become a powerful trade hub, home to Columbus
- 12. Disease brought by Europeans that devastated Native American populations
- 15. Major 16th-century movement that led to the creation of Protestant churches (12 letters)
- 16. The year Columbus "discovered" the Americas
- 18. Pre-Columbian city in Illinois, known for its large earthen mounds
