Constipation

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Across
  1. 4. This class of laxatives includes aloe, cascara, and senna/MOA: Activates enteric nerves to induce colonic contractions and increases fluid and Na+ secretion into the lumen. DOC for opioid-induced constipation
  2. 5. 17g of this product needs to be mixed with H2O or juice. Also commonly used in bowel prep for colonoscopies
  3. 9. Poorly absorbed sugar that takes 1-3 days to stimulate a bowel movement (ingredient in many candies)
  4. 10. _______ laxatives form emollient gels that absorb water back into the stool, which push against colon walls to stimulate peristalsis. Gas formation is a common side effect
  5. 14. Class of pain medications that commonly cause constipation
  6. 15. Chronic constipation includes symptoms lasting more than _______ weeks
  7. 17. Brand name for Prucalopride/MOA: Activates 5-HT4 receptors which facilitates the release of ACh, resulting in enhanced colonic peristalsis
  8. 18. Constipation is defined by less than _______ bowel movements per week with signs and symptoms
  9. 19. Brand name for methylnaltrexone/MOA: Mu opioid receptor antagonist, stimulates BM within 30 minutes
  10. 20. Poorly absorbed sugar that takes 1-3 days to stimulate a bowel movement (also used to treat hepatic encephalopathy)
Down
  1. 1. These types of agents are poorly absorbed sugars that draw water into the colon to stimulate BM
  2. 2. Non-pharmacological recommendations include 6-8 glasses of _______
  3. 3. Enteric coated tablets that activate enteric nerves to induce colonic contractions; also comes in 10 mg suppositories for quick onset
  4. 6. Recommend slowly increasing _______ into diet over 7-10 days
  5. 7. Stool softener that is not effective for active constipation
  6. 8. Brand name for methylcellulose
  7. 11. Brand name for Linaclotide/MOA: Increases chloride and bicarbonate secretions into the intestinal lumen, and inhibits Na+ reabsorption
  8. 12. Brand name of Lubiprostone/MOA: Activates Cl- channels to cause an influx of Na+ into the small intestine, increasing fluid movement into the intestinal lumen
  9. 13. Brand name for Naloxegol/ MOA: Mu opioid receptor antagonist
  10. 16. Brand name for psyllium