CREON: MEDICAL REFRESHER

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Across
  1. 4. Global AP incidence cases per 100000 population
  2. 6. Abbreviation for Severe Acute Pancreatitis
  3. 9. Protection provided to ensure complete enzyme delivery to the gut
  4. 11. The SD in the 120-push Creon bottle
  5. 13. Number of Creon capsules superior to two generic brand capsules
  6. 14. Advanced PEI can lead to loss of Bone Mineral content and this
  7. 16. The most common risk factor for CP
  8. 17. One of the three clinical features of CP along with pain and diabetes
  9. 19. Progressive fibro-inflammatory syndrome
  10. 20. Pancreatic tissue death that increases mortality to 17 percent
  11. 21. Site where Creon microspheres release enzymes at pH above 5
  12. 22. Acronym for replacement therapy
Down
  1. 1. Low water content in Creon ensures high enzyme integrity
  2. 2. Key enzyme that must be stable against proteolytic destruction
  3. 3. Process where enzymes injure the gland's own tissue
  4. 5. Rising incidence of this is a major cause of Acute Pancreatitis
  5. 7. The result of chronic maldigestion and weight loss
  6. 8. Fatty greasy stools resulting from malabsorption
  7. 10. Creon is the only brand with these True delivery units
  8. 12. Guidelines say this dose should be half of the main meal dose
  9. 15. One Creon capsule is superior to this many generic brand capsules
  10. 18. Journal where the 2021 study proving Creon superiority was published