Cystic Fibrosis

2. antibiotic use can kill what bacteria living in the lungs
3. leading cause of death in CF is ____ failure
8. protein activity is largely determined by the quantity & function of the protein
9. infection in the CF airway is _____ & a number of potentially dominant emerging pathogens are present
13. relatively common Gram-negative species cultured from sputum in CF
15. a main complication of CF that can be fatal
16. this disease remains the leading cause of morbidity & mortality in patients with CF
18. well recognized as an important pathogen which drives inflammatory responses & lung injury in CF
19. typical age the average person with CF will live to
20. another bacteria known to infect the CF airways

1. patients with CF often require higher doses of antibiotics for longer periods because of differences in antibiotic clearance & ______
4. this may be the result of the presence of bacteria that are commonly present within the CF airway microbiome & not grown in routine cultures
5. fungal infection in CF that seems to be ______ in prevalence
6. MRSA are strains of _____ that are resistant to commonly used antibiotics
7. within the lung, bacterial _____ are aggregates of microorganisms suspended in a matrix of self secreted proteins within the sputum
10. genetic disease that causes sticky thick mucus to build up in lungs & other organs
11. most common bacteria found in people with CF
12. _____ in CF patients commonly form biofilms, which renders them more resistant to a large spectrum of antibiotics
14. CF mainly affects this organ
17. the buildup of mucus in the lungs of people with CF can trap _____ & other microorganisms