Across
- 2. Nuclear process activated downstream of cytokine signaling.
- 5. Non self invader detected by innate immune cells.
- 6. Soluble immune mediators that coordinate systemic responses to infection.
- 9. Antiviral cytokine class essential for defense against viruses.
- 10. Molecule that binds specifically to a receptor to initiate signaling.
- 13. Functional outcome of interferon stimulated gene expression.
- 15. Cell surface protein that binds cytokine ligands to initiate signaling.
- 16. Sequential amplification process in intracellular signaling pathways.
- 17. Systemic signaling through the bloodstream.
- 20. Cytotoxic lymphocyte active in early antiviral defense.
- 21. Local signaling affecting neighboring cells.
- 22. Describes interferon receptor expression on nearly all nucleated cells.
- 23. Genes turned on in response to interferon receptor activation.
- 24. System responsible for distinguishing self from nonself.
- 25. Functional DNA unit whose expression is altered by cytokines.
Down
- 1. Post translational modification central to cytokine receptor pathways.
- 3. Tissue resident immune cells that detect invading pathogens.
- 4. Slower antigen specific immune response developing over days.
- 7. Intracellular cascade triggered after ligand receptor engagement.
- 8. Rapid first arm of immunity activated within minutes to hours.
- 11. Signaling mode where a cell responds to its own secreted cytokine.
- 12. Phagocytic cell that secretes cytokines upon activation.
- 14. Professional antigen presenting cell bridging innate and adaptive immunity.
- 18. Organelle where interferon stimulated genes are induced.
- 19. Route allowing cytokines to mediate total body responses.