Describe the pathophysiology and clinical manifestations of common and serious conditions affecting joints, such as osteoarthritis and gout

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Across
  1. 4. What is formed that looks like lumps as a result of this vicious battle between our immune system and the urate crystals??
  2. 7. What do the chondrocytes try to do in response to biomechanical injury in OA?
  3. 9. What state leads to gout from i.e. heavy ETOH consumption, corn syrup sugary drinks, red meat, decreased excretion of uric acid
  4. 12. What extracellular matrix component becomes degraded by chondrocytes releasing aggrecanases in early OA?
  5. 13. What can be seen on polarising light microscopy in gout?
  6. 14. What type of joint disease is Osteoarthritis?
  7. 15. What happens to chondrocytes to cause OA aetiology?
  8. 17. What do macrophages and neutrophils do to excess urate crystals in synovium?
Down
  1. 1. What detects the next step and results in maturation of pro-inflammatory cytokines (such as IL-1)?
  2. 2. What characteristic histological feature can be seen on articular cartilage? (Think AF)
  3. 3. The term to describe inflammation of joints
  4. 5. What are the mushroom shaped bony outgrowths that develop on the margins of the articular surface as a result of OA?
  5. 6. What happens to the poor old phagolysosomes trying to digest the ingested urate crystals (ouch)?
  6. 8. What subchondral pathology can be seen in late OA?
  7. 10. What enzyme does the gout drug Allopurinol inhibit in the purine uric acid pathway?
  8. 11. What connective tissue becomes degraded by chondrocytes releasing MMPs in early OA?
  9. 16. What happens to chondrocytes in late OA?