Detoxification of ammonia and urea biosynthesis

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Across
  1. 5. Another name for the urea cycle.
  2. 7. The pathway responsible for nitrogen excretion in birds and reptiles, which differs from the urea cycle
  3. 9. The compound formed by the combination of carbamoyl phosphate and ornithine.
  4. 11. The key allosteric activator of carbamoyl phosphate synthetase I.
  5. 13. An alternative non-toxic carrier of ammonia in the blood
  6. 17. The enzyme that catalyzes the first step of the urea cycle
  7. 18. The molecule that regulates urea cycle enzyme expression in response to dietary protein intake
  8. 19. The organelle where citrulline is transported after being synthesized in mitochondria.
Down
  1. 1. A toxic compound that accumulates in urea cycle disorders, leading to neurological damage
  2. 2. The enzyme that converts arginine to urea and ornithine
  3. 3. The enzyme responsible for converting glutamate to ammonia
  4. 4. The amino acid that transports ammonia from peripheral tissues to the liver.
  5. 6. The toxic compound produced from protein metabolism
  6. 8. Another name for the urea cycle.
  7. 10. The condition caused by urea cycle enzyme deficiencies
  8. 12. The cycle that links amino acid degradation with the urea cycle via fumarate.
  9. 14. The intermediate formed when citrulline reacts with aspartate in the urea cycle.
  10. 15. A tricarboxylic acid cycle intermediate that links the urea cycle to the Krebs cycle
  11. 16. The amino acid that donates an amino group in the urea cycle
  12. 20. A high-energy phosphate donor required in the first step of the urea cycle