Development of T cells

1. A subset of CD4 T cells is called _______ CD4 T cells.
5. commit to the T-cell lineage before rearranging their T-cell receptor genes
6. _____ involution the shrinking age of thymus with age
9. T-cell development gives rise to to two functionally different _______ of T cells.
11. _______ of an autoreactive CD4 T cell by a regulatory T cell is dependent on the interaction of both T cells with same antigen-presenting cell.
13. consits of mature thymocytes, medullary epithelial cells, dendritic cells, and amcrophages
14. MHC class I proteins display antigens from _______ pathogens.
16. ______ syndrome is a disorder caused when a small part of chromosome 22 is missing.
17. T cells specific for self antigens are removed in the thymus by negative selection.
19. MHC class II proteins are recognized by ______ T-cells.
20. ________ selection takes place in the cortex of the thymus.
21. consists of immature thymocytes, branched cortical epithelial cells, and a few macrophages.

2. MHC class II proteins display antigens from _____ pathogens.
3. The proportion of the thymus that produces T cells ______ with age.
4. ________ is dedicated to T-cell development and contains immature T cells, called thymocytes, which are embedded in a network of epithelial cells known as the thymic stroma.
7. Once a developing thymocyte expresses an α:β receptor and CD4
8. double ______ is both CD4+CD8+
10. T cells that undergo apoptosis are ingested by _______ in the thymic cortex.
12. double _____ cell has no CD4 or CD8
15. Positive selection determines _______ of either the CD4 or the CD9 co-receptor.
18. CD8 on its surface, it undergoes two types of selection— positive and negative—both of which involve ________ the receptor’s interactions with the complexes of self peptides bound by self-MHC molecules on the surface of thymic cells
19. MHC class I proteins are recognized by _____ T-cells.