Developmental and Cancer Genetics

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Across
  1. 2. This is a highly conserved stretch of DNA sequence present in Hox protein coding sequences
  2. 5. Tumor ________ genes are genes which are recessive when mutated, but can produce a cancer
  3. 10. This type of chemical can cause mutations in somatic cells
  4. 11. This type of gene makes a product that is deposited into an egg by the female
  5. 12. A _______ mutation makes the phenotype of another mutation more dramatic
  6. 14. In ________ division, the two daughter cells of mitosis and cytokinesis are nonidentical and can have different cell fates
  7. 16. This type of mutation affects more than one phenotype
  8. 17. When a cell’s fate is determined by a message it receives from another cell, cell to cell ______ has occurred
  9. 19. In ______ mutants, the identity of one body structure has been changed into another.
  10. 20. This is an example proto-oncogene; when mutated, it cannot be turned off.
Down
  1. 1. These genes encode proteins with functions necessary for cellular upkeep, metabolism and protein synthesis
  2. 3. This interesting property of Hox genes means that their expression order along the body of an animal is the same order they are found in on the chromosome.
  3. 4. This type of mutation makes cells more likely to accumulate genetic errors.
  4. 6. This is the process in which cells begin to express different sets of genes and ultimately become different tissue types.
  5. 7. This type of gene is dominant when mutated and can produce a cancer
  6. 8. Signal _______ is the general word for how an extracellular signal is passed through the cell membrane to effect things inside the cell
  7. 9. Cells acquire different tissue identities and fates by expressing different ____ factors
  8. 10. This technology uses small DNA probes to study the gene expression of many genes simultaneously by assaying all mRNA expressed in a tissue.
  9. 13. A cell that is going to divide must pass through several of these potential stopping points throughout the cell cycle
  10. 15. This type of mutation is passed on to one’s offspring
  11. 18. Programmed cell death, either during development or as “cellular suicide” for diseased cells