Across
- 5. HHS causes severe __________
- 7. occurs when energy is needed, with large molecules broken down into smaller ones
- 8. Type of linker between the lipophilic tail and acidic head group in thiazolidinediones?
- 9. this occurs when blood glucose is <70 mg/dL
- 11. DPP-4 inactivates which hormone?
- 16. endocrine organ that regulates blood glucose concentrations
- 19. brand name for Metformin
- 20. drug that inhibits gluconeogenesis
- 21. Drug that promotes satiety
- 23. A biosimilar basal (long-acting) insulin
Down
- 1. DPP-4 binds to this amino acid
- 2. structure needed to retain biological activity in sulfonylureas
- 3. Brand name for Aspart
- 4. Insulin sensitizers due to their agonist activity on PPAR-y
- 6. CYP enzyme that metabolizes saxagliptin
- 10. Insulin powder inhaler
- 12. Medication with many substitutions, the first one being A8 and G8. Plus, 10 amino acids are added to G35, folding the protein into a DPP-4 resistant shape.
- 13. Hormone that increases surface expression of GLUT4
- 14. stimulate insulin secretion by interacting with SUR1 receptors, without inducing hypoglycemia
- 15. These 3 analogs are fast acting for insulin: Glulisine, Lispro, and ____
- 17. Medications that target SUR1 receptors on beta-cells
- 18. Is C-peptide increased or decreased in the presence of high auto-antibodies against the pancreas?
- 22. Hormone produced by alpha cells and is suppressed following meals
- 23. analog of human amylin