Across
- 6. Skin finding associated with dehydration
- 9. Constitutively present in the sarcolemmal membrane of for basal glucose uptake.
- 10. Voltage-gated __ channels open in response to cell depolarization
- 11. Primary fuel source of muscles in the absence of insulin
- 14. Term for when non-resorbed glucose in kidney tubules prevents water from being resorbed, leading to dehydration
- 15. This region on chromosome 6 confers the strongest genetic risk for DM1
- 16. Inhibited by increased levels of CoA, resulting in decreased fatty acid oxidation
- 17. This treatment option exhibits no pronounced peak and has a lower risk of nocturnal hypoglycemia
- 18. Respiration pattern often exhibited by patients in DKA
- 20. Metabolic clearance of this product is reduced by 42% in people with DM1 compared to healthy controls.
- 22. __ risk factors play a strong role in whether someone who is genetically susceptible goes on to develop DM1
- 23. This organ disposes of over 50% of ingested glucose postprandially
Down
- 1. Metabolic process entered by the products of ketolysis
- 2. ATP-sensitive __ channels close in response to elevated ATP, causing membrane depolarization.
- 3. This pathway doubles the efficacy of Ca2+ on insulin release independent of further changes in intracellular [Ca2+]
- 4. Rate limiting enzyme of ketolysis
- 5. In adipose tissue, decreased blood flow is associated with __ insulin sensitivity
- 7. This treatment option must be administered within 15 minutes before, or immediately after a meal
- 8. Rate limiting enzyme of ketogenesis
- 12. This treatment option is usually administered twice daily and peaks 4-8 hours after administration
- 13. Phosphorylated in the presence of insulin, triggering the conversion of acetyle CoA to malonyl CoA
- 19. When the going gets tough, turn to __
- 21. __ of insulin-containing secretory granules is triggered by increased [Ca2+]