Drug Discovery & Metabolism

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Across
  1. 4. equivalent rings and/or functional groups having similar spatial dimensions and outer electrons
  2. 7. Using computational methods to design protein-dockable analogs as potential drug leads is known as ____-based drug discovery
  3. 8. A synonym for phase 1 metabolism
  4. 9. Organ responsible for first-pass metabolism
  5. 10. _____ modification is a drug discovery approach when substituents having and increasing number of CH2 units are generated for a series of analogs
  6. 11. A CYP450 inhibitor food item
Down
  1. 1. Prominent ring/functional group that defines a drug or a class of drugs
  2. 2. Important component of CYP450
  3. 3. percent of a drug which enters the circulation when introduced into the body
  4. 5. A common phase 2 metabolite
  5. 6. Classification of an enzyme belonging to the CYP450 family