enzyme crossword

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Across
  1. 3. new substance formed at the end of a chemical reaction
  2. 5. the active site having a set shape
  3. 7. a net release of free energy
  4. 11. organic cofactors
  5. 12. the sum of all chemical reactions occurring in the cell
Down
  1. 1. absorbs free energy from the surroundings
  2. 2. energy the energy required to start any reaction
  3. 4. breaking down large molecules to smaller ones
  4. 6. reduce or stop the enzyme from functioning
  5. 8. a flexible active site that changes shape, or conforms, to the substrate as they bond together.
  6. 9. the starting substance in a chemical reaction
  7. 10. making large molecules from smaller ones