enzyme puzzle

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Across
  1. 2. / enzyme lacked by lactose intolerant people
  2. 4. / rate of reaction as pH exceeds the optimum level
  3. 6. / enzymes that can be used many times, resulting in cost saving
  4. 7. / region on the surface of the enzyme to which the substrate binds and which catalyses the reaction
  5. 9. / induced by the substrate approaching the enzyme
  6. 12. / The substrate and active site match each other structurally and chemically
  7. 13. / reactant in a biochemical reaction
  8. 15. / change in the conformation of the protein
  9. 16. / globular protein that acts as a biological catalyst (increases the rate of reaction by lowering the activation energy threshold)
  10. 17. / enzymes attached to a material so that their movement is restricted
  11. 19. / affected by the substrate concentration
Down
  1. 1. / the substrate and active site happen to be correctly aligned to allow binding to take place
  2. 3. / Minimum energy required for the reactants to possess in order to undergo a chemical reaction
  3. 5. / contain proteases and lipases to break down stains
  4. 8. / coming together of a substrate and an active site
  5. 10. / can cause denaturation as vibrations in the molecule break the intermolecular bonds or interactions
  6. 11. / increase in rate of reaction caused by a globular protein
  7. 14. / enzyme that catalyses the conversion of hydrogen peroxide into water and oxygen
  8. 18. / used in cheese production