Erik Vint 761

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Across
  1. 2. HSV-1 virus that lyses tumor cells
  2. 4. Monoclonal Ab, can decrease LVEF
  3. 6. HDA inhibitor, can cause taste changes and anemia
  4. 7. proteasome inhibitor, irreversible inhibitor of 20S proteasome
  5. 9. HDA inhibitor, causes severe thrombocytopenia and diarrhea
  6. 10. TK inhibitor, elevated INR if given with Warfarin
  7. 11. Monoclonal Ab, can cause fatal GI perforation
  8. 12. HHP inhibitor, can cause alopecia and joint pain
  9. 14. mTOR inhibitor, contraindicated if bilirubin is 1.5 times the ULN
  10. 17. Proteasome inhibitor, blocks activity at 26S proteasome
  11. 21. proteasome inhibitor, reversibly inhibits beta5 subunit of 20S proteasome
  12. 23. Monoclonal Ab, can cause PML from JC virus
  13. 24. inhibits PARP
Down
  1. 1. inhibits delta phosphatidylinositol 3-kinase
  2. 3. TK inhibitor, used for Ph+ CML and ALL
  3. 5. VEGF inhibitor, BBW for GI perforation, hemorrhage, and impaired wound healing
  4. 8. inhibits CDK 4 and 6
  5. 13. TK inhibitor, binds BCR-ABL
  6. 15. TK inhibitor, inhibits both EGFR and HER2
  7. 16. HHP inhibitor, can increase SCr, CK, and AST/ALT
  8. 18. brand name for drug that delivers diphtheria toxin and IL2
  9. 19. mTOR inhibitor, can cause new onset T2DM
  10. 20. HDA inhibitor, used for relapsed/refractory T-cell lymphoma
  11. 22. Monoclonal Ab, KRAS mutation renders ineffective