Exam #2: BHS 316

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Across
  1. 2. The _____ is guarding the groove of the MHC molecule.
  2. 6. _____ proteins are responsible making sure CTLA-4 and PD-1 function properly to help decommission T cells as a negative immune regulator.
  3. 9. Unlike B cells, T cells cannot undergo ______ to change the affinity of their TCRs for their cognate antigen.
  4. 10. _____ co-receptors will only clip onto class I MHC molecules.
  5. 12. Activated _____ cells recruit their own replacements.
  6. 13. Lymphoid follicles are specialized regions of _____ lymphoid organs in which B cells percolate through a lattice of follicular dendritic cells.
  7. 15. _____ co-receptors will only clip onto class II MHC molecules.
  8. 16. What type of antibodies does a virgin B cell mainly produce when first activated?
  9. 18. What type of cytokines will help you when you are attacked by fungi or extracellular bacteria?
  10. 19. ______ that bind to Class II molecules are longer than those that occupy the closed groove of class I molecules.
  11. 20. T cells require extensive receptor _____ by MHC peptide complexes.
Down
  1. 1. signaling involves clustering ____ together in one area of the T cell surface.
  2. 3. In response to antigens, virgin B cells can be activated with minimal help from the T cell. This is known as T cell - ______.
  3. 4. Dendritic cells function as a _____ between the innate and adaptive systems.
  4. 5. An external region which binds to a molecule, involved in transmembrane proteins.
  5. 7. What type of antibody is least abundant in the human body?
  6. 8. What type of cytokine is responsible for instructing the innate and adaptive systems to mobilize cells and produce antibodies that are effective against invaders?
  7. 10. Movement of the immune system through a lymph node is orchestrated by up and downregulation of chemokine receptors and _____.
  8. 11. _____ is made of a heavy chain and a light chain.
  9. 14. The ____ region of an antibody determines both its class and its function.
  10. 15. Antibody class switching is controlled by the ____ that B cells encounter to switch place.
  11. 17. What type of B cell produces one kind of BC or antibody?