Across
- 2. covalently binds to itself to prevent DNA polymerase from dissociation
- 4. unwinds DNA during replicaiton
- 5. help stabilize new dNTPs and facilitate bonding between new dNTPs
- 7. helps relieve supercoiling during replication
- 9. catalytic site on DNA polymerase which monitors the addition of new dNTPs
- 11. a genetic disease found in native american tribes that prevents UV damage repair
- 14. isomers which form different forms of molecules not ideal for nucleotide addition
- 15. cuts in the center of a DNA strand
- 16. the removal of an amino acid that cause dna damage
- 17. recognizes mismatch mutations and recruits mutl and muth
- 20. during transcription this enzyme copies DNA sequences to create new RNA strands
- 21. describes an enzyme that can catalyze multiple reactions without dissociating from the substrate
Down
- 1. prevents degradation on the ends of DNA
- 3. extends telomeres by adding nucleotides
- 6. site where two strands of DNA are separated to initiate replication
- 8. the physical transfer of DNA sequences between chromosomes
- 10. cuts on the end of DNA strands
- 12. forms a filament around DNA and extends DNA strands
- 13. site where 4 single-stranded DNA molecules meet during recombination
- 18. responsible for adding new nucleotides to DNA
- 19. closes nicks in DNA after base excision