Exam 2 Prep

2. Organ where T cells are taught self-tolerance
7. A virgin T cell that can no longer perform due to a lack of co-stimulation even though it has recognized its cognate antigen presented on a cell is said to be
8. Cells that transport antigen to Peyer’s patches.
9. Virgin T cells circulate through the secondary lymphoid organs but are not allowed in the _______.
12. _________ selection tests T cells for tolerance of self.
14. A group of chemical messengers secreted by helper T cells that serve to provide instructions to the rest of the immune stystem
15. Somatic hypermutation and class switching happen in the ______ zone.
16. Hypothesis that states that to survive both positive and negative selection in the thymus, T cells must have receptors that are ‘just right’.
17. The secondary lymphoid organ that filters blood

1. Proteins found on many of the body’s tissues are ______ proteins.
3. A lymphoid follicle that has grown and become the center of B cells development is called a _______ center.
4. Peyer’s patches are an example of this type of secondary lymphoid organ (acronym).
5. transcription factor produced by mTEC that drives expression of about 3000 different tissue specific antigens
6. The component produced by CTLs that punches a hole into an infected cell’s membrane
10. Receptors on NK surface that recognize class I MHC on healthy cells as a ‘don’t kill’ signal.
11. A T cell expressing either CD4 or CD8, but not both is known as a _______ positive T cell.
13. _________ selection is the process for testing T cells for MHC restriction.
14. The specialized cytokines that choreograph immune cell movement in secondary lymphoid organs.