Across
- 3. antibody isotype that is usually membrane bound on B cells and acts as the B cell receptor
- 5. antibody isotype that is found in mucosa
- 7. can bind to CD80 or CD86; key co-stimulatory signal to tell the T cell to activate; on all naive mature T cells when they leave the thymus
- 8. T cell proliferation from a single activated T cell
- 9. antibody isotype with the longest antibody half life; opsonizes pathogens; induces phagocytosis; induces classic complement; transported via transcytosis across placenta
- 10. the type of t cells the help protect epithelial and mucosal barriers, defense against extracellular bacteria and fungi; secretes IL-17 and IL-22
- 13. a disease that results in low or no T cells; clinically presents as frequent and sever infections, especially viral, and fungal; universally fatal before 2 years old
- 16. the type of B cell that is a non-dividing cell until re-stimulated with antigen at a later time; make high affinity IgG, IgA, or IgE and express them on plasma membrane
- 18. x-linked immunodeficiency; defects in WASP which typically aids cytoskeletal actin rearrangement; this primarily affects leukocytes and platelets
- 20. the type of B cell that is non-dividing, antibody-secreting
- 22. the type of T cells that are the classic helper cells of cell-mediated response; help control intracellular infections; makes cytokines IFN-gamma, TNF-alpha, and IL-2
- 23. the type of t cells that reside in secondary lymph tissues and interact with B cells in germinal centers; induced by IL-21; secretes IL-21
- 24. search for infected (or cancerous) cells and kill them; induce target cell apoptosis via perforin, granzymes, FasL; also activate macrophages via IFN gamma
- 25. expressed on activated T cells, binds to PD-L1 or L2
Down
- 1. the type of signaling used when a T cell makes IL-2 that acts on itself
- 2. induces T cell proliferation and enhances T cell survival
- 4. large chromosomal deletion on chromosome 22, poor or absent thymus development; treat with thymic transplant
- 6. the cell type that is short-lived and migrates to tissues to control the infection
- 11. antibody isotype that acts as the B cell receptor; sereted it can opsonize pathogens and induce classic complement
- 12. the type of t cell that develop in thymus and peripheral tissues, usually are specific for self-antigens, prevent autoimmunity; induced by IL-10 and TGF beta
- 14. antibody isotype that is secreted to protect from parasites and venoms; involved in allergy development
- 15. a bacterial toxin that can bind the TCR on the external side and results in widespread, non-specific T cell activation, cytokine release, and toxic shock
- 17. the cell type that is long-lived and are quiescent until a later exposure to antigen years later
- 19. found on T cells; binds ICAM-1 on APCs; helps in cell-cell adhesion
- 21. binds to B71 or B72, prevents APCs from stimulating other T cells
- 22. the type of t cells that control helminth infections, and the defense from toxins, venoms, and insect bites; they also play a role in allergies and asthma; secrete IL-4, IL-5, and IL-13