Across
- 2. Most severe form of holoprosencephaly characterized by a single common ventricle and a malformed brain
- 4. Closed defect of the spine without protrusion of meninges or spinal cord
- 7. Open spinal defect characterized by protrusion of the spinal meninges
- 8. Enlargement of the fetal cranium as a result of ventriculomegaly
- 9. Form of holoprosencephaly characterized by a common ventricle, hypotelorism, and a nose with a single nostril
- 11. Severe form of holoprosencephaly characterized by a common ventricle, fusion of the orbits with one or two eyes present, and a proboscis
- 12. Open spinal defect characterized by protrusion of meninges and spinal cord through the defect, usually within a meningeal sac
- 13. An abnormality or congenital malformation
- 14. Congenital absence of the cerebral hemispheres caused by occlusion of the carotid arteries; midbrain structures are present, and fluid replaces cerebral tissue
- 15. Neural tube defect of the spine in which the dorsal vertebrae fail to fuse together, allowing the protrusion of meninges and/or spinal cord through the defect
Down
- 1. Abnormal accumulation of cerebrospinal fluid within the cerebral ventricles leading to dilatation of the ventricles; compression of developing brain tissue and brain damage may result; commonly associated with additional fetal anomalies
- 3. Increase in size of the jugular lymphatic sacs caused by abnormal development
- 5. Neural tube defect characterized by lack of development of the cerebral and cerebellar hemispheres and cranial vault; this abnormality is incompatible with life
- 6. Ventriculomegaly in the neonate; abnormal accumulation of cerebrospinal fluid within the cerebral ventricles resulting in compression and, frequently, destruction of brain tissue
- 10. Range of abnormalities resulting from abnormal cleavage of the forebrain
- 13. Condition associated with anencephaly in which there is complete or partial absence of the cranial bones