Final year biomedical student: coagulation cascade

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Across
  1. 2. Factor that forms a complex with factor VIII to activate factor X. (8 letters: _ _ _ _ _ _ _ _)
  2. 4. An enzyme generated from prothrombin that catalyzes fibrinogen to fibrin. (9 letters)
  3. 7. An anticoagulant protein that, along with protein S, inactivates factor V and VIII. (6 letters)
  4. 10. This factor is also known as Hageman factor and plays a role in initiating the intrinsic pathway. (8 letters)
  5. 11. A pathway in the coagulation cascade that's triggered when blood comes into contact with collagen. (9 letters)
  6. 12. Factor activated by the extrinsic pathway, sometimes used as a synonym for the tissue factor. (6 letters)
  7. 13. Inherited disorder characterized by the deficiency or dysfunction of Factor VIII. (9 letters)
Down
  1. 1. This zymogen is the precursor of the enzyme that catalyzes the final step in the coagulation cascade. (11 letters)
  2. 3. Common name for Factor I, the final protein substrate in the coagulation cascade. (9 letters)
  3. 4. Common name for Factor III, which starts the extrinsic pathway. (6 letters)
  4. 5. The condition caused by the absence or dysfunction of Factor IX. (8, 8 letters: _ _ _ _ _ _ _ _ - _ _ _ _ _ _ _ _)
  5. 6. The pathway triggered by damage outside the vascular system, often via trauma or injury. (9 letters)
  6. 8. The final product of the coagulation cascade, forming a mesh to stabilize platelet plugs. (6 letters)
  7. 9. Protein, often used in laboratory testing, which when combined with calcium activates the extrinsic pathway. (6 letters)
  8. 10. Activated by thrombin, this factor strengthens the fibrin clot by cross-linking fibers. (6 letters)