General Pharmacology

2. Reduced response to a drug due to prolonged exposure.
4. A substance that inhibits or blocks the effect of a receptor.
6. kinetics Drug elimination at a constant rate, regardless of concentration.
9. state The point at which drug intake equals drug elimination.
12. effect The metabolism of a drug before it reaches systemic circulation.
14. effects Unintended effects of a drug at therapeutic doses.
17. When two drugs have comparable bioavailability and effects.
19. Rapid decrease in response to a drug after repeated administration.
20. dose The dose required to maintain drug levels within the therapeutic range.
22. effect The therapeutic benefit from an inactive substance due to expectation.
23. The study of the biochemical and physiological effects of drugs and their mechanisms of action.
26. The volume of plasma cleared of a drug per unit time.
27. A protein molecule that binds to a drug to mediate its action.

1. kinetics Drug elimination proportional to its concentration.
3. reaction An unusual or unexpected reaction to a drug in an individual.
5. inhibition The decrease of enzyme activity by a drug.
7. site A binding site on a receptor different from the active site.
8. The time required for the concentration of a drug to reduce by half.
10. The ability of a drug to produce the maximum desired effect.
11. of distribution A theoretical volume that relates drug dose to plasma concentration.
13. The amount of a drug needed to produce a specific effect.
15. The proportion of a drug that enters the systemic circulation unchanged.
16. dose A higher initial dose of a drug to rapidly achieve therapeutic levels.
18. The study of drug absorption, distribution, metabolism, and excretion.
19. The harmful effects of a drug at high doses.
21. index The ratio of a drug's toxic dose to its effective dose.
22. A compound that becomes active only after metabolic conversion.
24. A substance that activates a receptor to produce a biological response.
25. interaction The modification of a drug's effect by another drug or substance.
26. enzymes A group of enzymes involved in drug metabolism.