Across
- 5. basic drugs bind to it (ppb)
- 8. rate and extent of bioavailability of active drug from two drugs is not significantly different under suitable conditions
- 9. weak electrolyte crossing a membrane to encounter a PH from which it is not able to escape easily
Down
- 1. acidic drugs bind to it (ppb)
- 2. presence of it dilutes drug and retards absorption
- 3. essentially foreign substances
- 4. drugs get initially distributed to organs with high blood flow later to less vascular more bulky tissues
- 6. weakly basic drugs ionize at this ph
- 7. it limits the entry of non-lipid soluble drugs in brain