Gout

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Across
  1. 8. pivotal elements in the host defense of humoral immunity
  2. 12. the body creates uric acid when breaking down this substance
  3. 13. this results from deposition of MSU crystals in joint tissues
  4. 15. MSU crystals can cause this to happen to bones
  5. 17. gout occurs more often in this gender
  6. 18. this factor is expressed with gout
  7. 20. gout can cause _____ of joints
  8. 23. NLRs are key ____ innate immunity regulators
  9. 24. ______ is also associated with augmented CD20+B cells
  10. 29. uric acid normally passes through your ____ into your urine
  11. 30. _____ of monosodium urate (MSU) crystals are found in articular tissue
  12. 31. B-lymphocytes are involved in the _____ immune response in gout
  13. 33. MSU formation can be influenced by these levels
  14. 35. gout inflammation is generally ____
  15. 37. activated neutrophils bring about neutrophil ____
  16. 39. several urate-_____ drugs are available
  17. 43. 1β has a key role in gout initiation
  18. 44. these cells are capable of secreting IL-1β and activating the NLRP3 inflammasome
  19. 45. activation of this inflammasome initiates gout flares
  20. 47. induces the immune response
  21. 48. gout is a type of this common disease
  22. 49. local ____ are activated in the early response
  23. 50. crystals that form in the presence of increased urate concentrations
Down
  1. 1. gout is a(n) _____ arthritis
  2. 2. long-term lowering of serum urate to less than 360 μmol/L leads to crystal _____
  3. 3. rates of initiation and continuation of urate-lowering therapy are _____
  4. 4. innate immunity is formed in this kind of development
  5. 5. a chronic disease of deposition of monosodium urate crystals
  6. 6. sweetened beverages which can cause gout contain this
  7. 7. recent ____ may trigger gout
  8. 9. "treat to target serum urate" approach is essential for gout _____
  9. 10. a(n) _____ dose-escalation strategy is effective for achieving treatment targets
  10. 11. achievement of serum urate targets is ______
  11. 14. a gout attack can occur _____
  12. 16. T cells participate in adaptive immune responses via promoting _____
  13. 19. these immune cells are involved in the inflammatory process of gout
  14. 21. gout affects _____ genders
  15. 22. activated when met with uric acid crystals
  16. 25. deposits of urate crystals under the skin
  17. 26. gout is characterized by high sustained levels of uric _____
  18. 27. gout is most common in this country
  19. 28. receptors on the immune cells cannot directly ___ with MSU crystals
  20. 32. gout often affects which toe?
  21. 34. NLRs are pivotal in perceiving these structures
  22. 36. gout can affect which people?
  23. 38. the process of gout is _____
  24. 40. B cells promote _____ via the generation of immunoglobulins
  25. 41. these cells may be involved in gouty inflammation
  26. 42. the urate crystals associated with gout
  27. 46. neutrophils flood into this fluid