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Across
  1. 4. Youngest player to win National League MVP
  2. 5. Sheldon's online show
  3. 6. John Galecki's character on Big Bang Theory
  4. 11. First Nationals player to win National League Player of the Month twice in a season
  5. 12. Team that became the Washington Nationals
  6. 13. She played Amy on Big Bang Theory
  7. 14. Howard and Bernadette's daughter
  8. 16. What Bernadette might have been if not a microbiologist
  9. 18. Reaction used by the oriental hornet to store power for nighttime activity
  10. 22. It organizes DNA by forming a scaffolding
  11. 23. Pitcher who pitched a complete game giving up 0 earned runs and lost
  12. 25. A pyrimidine base that can form dimers when exposed to UV radiation
  13. 26. Composition written for an instrumental soloist
  14. 28. Sheldon's middle name
  15. 29. Setting for Monk
Down
  1. 1. First Nationals player to hit a grand slam
  2. 2. Substrate in the Krebs cycle
  3. 3. Raj's dog's name
  4. 7. A poem sung in Beethoven's 9th Symphony
  5. 8. Maker of what is now the world's most expensive viola
  6. 9. Howard's astronaut nickname
  7. 10. What Bernadette might have been if not a microbiologist
  8. 15. Monk's boss
  9. 17. Technique of combining multiple melodic lines of which Bach was a master
  10. 19. first pitcher to throw two no-hitters in the regular season
  11. 20. Spindle fibers attach to these during metaphase
  12. 21. Italian credited with making the first modern violins
  13. 24. In Big Bang Theory her face is never seen
  14. 25. Monk's wife
  15. 27. Misspelling that appeared on a Jersey in 2009
  16. 28. Steroid and waxes e.g.
  17. 30. The strings of a cello